(Thio)nicotinamide ribofuranoside salts and compositions, methods of making, and uses thereof

A crystalline nicotinamide-2,3,5-tri-O-acetyl-β-D-ribofuranoside bromide of formula O-Va:

• wherein R is acetyl, characterized by a powder X-ray diffraction pattern substantially as defined in FIG. 1;
• or
• a crystalline nicotinamide-β-D-ribofuranoside bromide of formula O-Ia:
• characterized by a powder X-ray diffraction pattern substantially as defined in FIG. 2;
• or
• a crystalline nicotinamide-β-D-ribofuranoside chloride of formula O-Ib:
• characterized by a powder X-ray diffraction pattern as defined in FIG. 4;
• or
• a crystalline thionicotinamide-2,3,5-tri-O-acetyl-β-D-ribofuranoside bromide of formula S-Va:
• wherein R is acetyl, characterized by a powder X-ray diffraction pattern substantially as defined in FIG. 5;
• or
• a crystalline thionicotinamide-β-D-ribofuranoside bromide of formula S-Ia:
• characterized by a powder X-ray diffraction pattern substantially as defined in FIG. 6;
• or
• a crystalline thionicotinamide-β-D-ribofuranoside chloride of formula S-Ib:
• characterized by a powder X-ray diffraction pattern substantially as defined in FIG. 7;
• or
• a crystalline thionicotinamide-2,3,5-tri-O-acetyl-β-D-ribofuranoside chloride of formula S-Vb:
• wherein R is acetyl, characterized by a powder X-ray diffraction pattern substantially as defined in FIG. 8.