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US 12,180,228 B2Granted
Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
AssigneeMassachusetts Institute of Technology
InventorsMohammad Movassaghi, Chase Robert Olsson, Tony Z. Scott, Jaime Cheah, Joshua Nathaniel Payette
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Abstract
The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines.
Claims21
A compound having the structure of Formula (X):
- or salt thereof, wherein
- RX is unsubstituted alkyl, -Si(RS)3, -Sn(RS)3, substituted or unsubstituted benzyl, or MX;
- RY is unsubstituted alkyl, -Si(RS)3, -Sn(RS)3, substituted or unsubstituted benzyl, hydrogen, or MY;
- each RS is independently hydrogen, halogen, hydroxyl, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C1-6 heteroalkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- MX is a metal selected from the group consisting of sodium, potassium, lithium, rubidium, and cesium;
- and
- MY is a metal selected from the group consisting of sodium, potassium, lithium, rubidium, and cesium.
4 more elements
Dependencies are inferred from the claim text.