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US 12,180,214 B2Granted
Crystalline forms of (s)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazine-7-yl)ethyl)amino)pyrimidine-5-carbonitrile as inhibitors of phosphatidylinositol-3-kinase
AssigneeHutchison Medipharma Limited
InventorsZhenping Wu, Wenji Li, Ling Feng
Life of this patent
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Abstract
The present invention belongs to the pharmaceutical field, and provides crystalline forms, solvates and the crystalline forms thereof of the compound (S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbonitrile of the formula shown below, and the pharmaceutical compositions comprising the same as well as the methods of preparing the same and the use thereof.
Claims18
A crystalline form of (S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbonitrile of the Formula A:
- wherein the crystalline form is Form V;
- and
- wherein crystalline Form V is characterized by an X-ray powder diffractogram comprising characteristic peaks at diffraction angles (°2θ) of 7.3°±0.2°2θ, 11.60±0.2°2θ, 14.60±0.2°2θ, 19.3°±0.2° 2θ, and 23.4°±0.2°2θ.
Dependencies are inferred from the claim text.