Substituted pyrazoles showing serotonin 5-HT receptor activity

A compound of Formula (1):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• Ring Q1 is Formula (2):
• wherein:
• wherein:
• Ring Q3 is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, cyano, C1-6 alkyl, NH2, OH, OC1-6 alkyl, and C3-10 cycloalkyl;
• wherein each C1-6 alkyl substituent of Ring Q3 is optionally and independently substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen and OC1-6 alkyl;
• wherein each NH2 substituent of Ring Q3 is optionally and independently substituted with 1 or 2 independently selected C1-6 alkyl substituents;
• wherein each OC1-6 alkyl substituent of Ring Q3 is optionally and independently substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen and a saturated 4- to 8-membered heterocyclyl;
• and
• wherein each C3-10 cycloalkyl substituent of Ring Q3 is optionally and independently substituted with 1, 2, or 3 independently selected halogen substituents;
• W is —CRCRD—;
• RC is hydrogen, C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl, wherein the C1-6 alkyl, OC1-6 alkyl, or C30 cycloalkyl is optionally substituted with 1, 2, or 3 independently selected halogen substituents;
• RD is hydrogen, C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl, wherein the C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl is optionally substituted with 1, 2, or 3 independently selected halogen substituents;
• m is 1;
• bond (b) is a single bond or double bond;
• X is CRE or —CRFRG;
• RE is hydrogen, C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl, wherein the C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl is optionally substituted with 1, 2, or 3 independently selected halogen substituents;
• RF is hydrogen, C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl, wherein the C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl is optionally substituted with 1, 2, or 3 independently selected halogen substituents;
• RG is hydrogen, C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl, wherein the C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl is optionally substituted with 1, 2, or 3 independently selected halogen substituents;
• or
• when RF and RG are each C1-6 alkyl, RF and RG, taken together with the carbon atom to which they are attached, form a saturated 3- to 6-membered carbocyclyl;
• Y is CRH or N;
• RH is hydrogen, C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl, wherein the C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl is optionally substituted with 1, 2, or 3 independently selected halogen substituents;
• and
• is the point of attachment to V;
• each V is independently —CRARB—;
• each RA is independently hydrogen, C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl, wherein each C1-6 alkyl, OC1-6 alkyl, and C3-10 cycloalkyl is optionally and independently substituted with 1, 2, or 3 independently selected halogen substituents;
• each RB is independently hydrogen, C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl, wherein each C1-6 alkyl, OC1-6 alkyl, and C3-10 cycloalkyl is optionally and independently substituted with 1, 2, or 3 independently selected halogen substituents;
• n is 1 or 2;
• bond (a) is a single bond or double bond;
• R1a is hydrogen, halogen, or C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with 1, 2, or 3 independently selected halogen substituents;
• R1b is hydrogen, halogen, or C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with 1, 2, or 3 independently selected halogen substituents;
• R1c is hydrogen, halogen, or C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with 1, 2, or 3 independently selected halogen substituents;
• R1d is hydrogen, halogen, or C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with 1, 2, or 3 independently selected halogen substituents;
• Z is C, CR, or N;
• RJ is hydrogen, C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl, wherein the C1-6 alkyl, OC1-6 alkyl, or C3-10 cycloalkyl is optionally substituted with 1, 2, or 3 independently selected halogen substituents;
• t is 1, 2, or 3;
• and
• Ring Q2 is Formula (3a) or Formula (3b):
• wherein:
• R2a is hydrogen;
• R2b is hydrogen;
• R2c is hydrogen;
• R2d is hydrogen;
• and
• is the point of attachment to Z;
• with the provisos that:
• (1) when bond (a) is a double bond, then Z is C;
• (2) when bond (b) is a single bond, then X is —CRFRG—;
• and
• (3) when bond (b) is a double bond, then X is CRES.