Aceclidine derivatives, compositions thereof and methods of use thereof
AssigneeLenz Therapeutics Operations, Inc.
InventorGerald Horn
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Abstract
The present invention is directed to derivatives of aceclidine. The present invention is further directed to ophthalmological compositions comprising a therapeutically effective amount of a compound of the present invention and one or more pharmaceutically acceptable excipients. The present invention is further directed to a methods of treating presbyopia or glaucoma or reducing hyperemia comprising administering to a patient in need thereof a therapeutically effective amount of a compound of the present invention.
Claims6
A pharmaceutically acceptable salt of a compound comprising a cation of formula (I),
- wherein R1 is an alkyl, and
- wherein R2 is an amine or tert-butyl.
An ophthalmological composition comprising a therapeutically effective amount of (i) a pharmaceutically acceptable salt of a compound comprising a cation of formula (I):
- wherein R1 is an alkyl, and
- wherein R2 is an amine or tert-butyl, or
- (ii) a compound of formula (III)
- or a pharmaceutically acceptable salt thereof,
- wherein the pH of the composition is at least 3 log units less than the pKa of the compound.
A method of treating presbyopia or glaucoma comprising administering to a patient in need thereof a therapeutically effective amount of (i) a pharmaceutically acceptable salt of a compound comprising a cation of formula (I):
- wherein R1 is an alkyl, and
- wherein R2 is an amine or tert-butyl, or
- (ii) a compound of formula (III)
- or a pharmaceutically acceptable salt thereof.
A method of reducing hyperemia comprising administering to a patient in need thereof a therapeutically effective amount of (i) a pharmaceutically acceptable salt of a compound comprising a cation of formula (I):
- wherein R1 is an alkyl, and
- wherein R2 is an amine or tert-butyl, or
- (ii) a compound of formula (III)
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.