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US 12,180,205 B2Granted
O-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors
AssigneeBiogen MA Inc.
InventorsNathan Genung, Kevin M. Guckian, Jeffrey Vessels, Lei Zhang, Ryan Gianatassio, Edward Yin Shiang Lin, Zhili Xin
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Abstract
Described herein are compounds represented by formulas (IA) or (IB) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of preparing and using the same. The variables R1, R3, R4, Y1, Y2, Ar, Z and n are as defined herein.
Claims20
A compound represented by the following structural formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- Ar is optionally substituted pyridinyl, optionally substituted pyrimidinyl, optionally substituted pyrazinyl, or optionally substituted pyridazinyl;
- n is 0, 1, or 2;
- and
- when n is other than 0, R1, for each occurrence, is independently halo or C1-C4 alkyl.
2 more elements
A compound represented by the following structural formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- Ar is optionally substituted pyridinyl, optionally substituted pyrimidinyl, optionally substituted pyrazinyl, or optionally substituted pyridazinyl;
- n is 0, 1, or 2;
- and
- when n is other than 0, R1, for each occurrence, is independently halo or C1-C4 alkyl.
2 more elements
Dependencies are inferred from the claim text.