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US 12,180,189 B2Granted
Proteostasis regulators
AssigneeKineta, Inc.
InventorsMegan Foley, Bradley Tait, Matthew Cullen
Life of this patent
Estimating the term…
Abstract
The present invention is directed to compounds having the Formulae (Ia-Ie), (II), (IIIa-IIId), (IVa-IVc), (Va-Vb), (VIa-VIe), (VII), (VIIIa-VIIIc), and (IX), pharmaceutically acceptable salts, prodrugs and solvates thereof, compositions of any of thereof and methods for the treatment of a condition associated with a dysfunction in proteostasis comprising an effective amount of these compounds.
Claims10
A compound having the Formula (VII):
- or a pharmaceutically acceptable salt thereof;
- wherein:
- Ring T is a ring selected from the group consisting of:
- A6 is phenyl substituted with halogen;
- each Rd is independently hydrogen or methyl;
- R16 and R17 are hydrogen;
- Z6 is selected from the group consisting of optionally substituted C3-C12 cycloalkyl, optionally substituted heterocyclic, optionally substituted aryl, optionally substituted heteroaryl and NRcRc;
- each Rc is independently selected from the group consisting of optionally substituted C1-C10 alkyl, and optionally substituted C3-C12 cycloalkyl;
- alternatively, two Rc groups are taken together with the nitrogen atom which they are attached to form a optionally substituted 3- to 8-membered heterocycle;
- and
- n is 0, 1 or 2.
8 more elements
A compound, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from:
Dependencies are inferred from the claim text.