Fluorinated empathogens
AssigneeAlexander Shulgin Research Institute, Inc.
InventorsNicholas V Cozzi, Paul F Daley
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Abstract
Provided are fluorinated analogs of MDMA, including fluorinated empathogens. In some embodiments, such compounds are monoamine releasers or inhibit monoamine transporters. In some aspects, features of the compounds provide stability, such as metabolic stability, and efficacy. Also provided are methods for the preparation of fluorinated empathogens and pharmaceutical compositions comprising the same. Methods of using the fluorinated empathogens, alone or in combination with other therapeutic agents, are provided. In some embodiments, fluorinated empathogens are used to treat CNS disorders, such as mental health conditions and neurodegenerative disorders.
Claims15
A compound of any of Formulas (IIIA), (IIIC), (IIID), (IIIE), (IIIF), (IVA), (IVB), (IVC), (IVD), (IVE), or (IVF):
- wherein each Y is independently protium (H) or fluorine (F), and
- wherein at least one Y is fluorine (F) and the remaining Ys are protium (H);
- or a pharmaceutically acceptable salt, prodrug, hydrate, or solvate thereof;
- provided that the compound is not
- (3,4-methylenedioxy-N-trifluoroethylamphetamine, MDTFEA).
Dependencies are inferred from the claim text.