US 12,179,195 B2 · Bioprocessing fluid sensor arrangement

Abstract

The present invention relates to a bioprocessing fluid sensor arrangement (100) for sensing fluidic properties in a process fluid path with a sensor (S), configured for aseptically connecting the sensor with at least one conditioning fluid while separating said sensor from the process fluid to at least one conditioning fluid e.g. for calibration, cleaning, regenerating and/or storing the sensor, the arrangement comprising a process fluid path (PF) having a process fluid inlet (PI) and a process fluid outlet (PO); a sensor (S) arranged in the process fluid path (PF); a bypass fluid path (BF) in the process fluid path (PF), for bypassing the sensor (S); a conditioning or cleaning fluid path (CF) having an inlet (CI) and an outlet (CO) each aseptically and fluidically connected to the process fluid path (PF), one on each side of the sensor (S); and flow controls (FC) for controlling the flow of fluids, whereby fluids can be controlled to flow either in the process fluid path (PF) via the sensor (S), or in the bypass fluid path (BF) omitting the sensor from the fluid path (PF), or in the conditioning or cleaning fluid path (CF) including the sensor in said flow but omitting the remaining process fluid path (PF) and bypass fluid path (BF).

Claims15

Dependent claims

A bioprocessing fluid sensor arrangement for sensing fluidic properties in a process fluid path with a sensor, configured for aseptically connecting the sensor with at least one conditioning fluid while separating said sensor from the process fluid to at least one conditioning fluid e.g. for calibration, cleaning, regenerating and/or storing the sensor, the arrangement comprising:

a process fluid path having a process fluid inlet and a process fluid outlet;
a sensor arranged in the process fluid path;
a bypass fluid path in the process fluid path, for bypassing the sensor, comprising a bypass inlet and a bypass outlet, one on each side of the sensor;
a conditioning or cleaning fluid path having an inlet and an outlet each aseptically and fluidically connected to the process fluid path, one on each side of the sensor, and each positioned between the bypass inlet and the bypass outlet;
and flow controls comprising a processor programmed for controlling the flow of fluids, whereby fluids can be controlled to flow in each of a) the process fluid path via the sensor, b) the bypass fluid path omitting the sensor from the fluid path, and c) the conditioning or cleaning fluid path including the sensor in said flow but omitting other portions of the process fluid path and bypass fluid path.

2 more elements

A bioprocessing sensor unit for sensing fluidic properties in a process fluid path and further configured for aseptic sensor connection to additional conditioning or cleaning or bypass fluid paths, comprising:

a body,
process couplers, coupled to the body and configured to provide aseptic connection via a process fluid inlet and a process fluid outlet of the sensor unit,
a bypass inlet and a bypass outlet positioned one on each side of the sensor unit,
conditioning couplers coupled to the body and configured to provide aseptic connection via a conditioning fluid inlet and a conditioning fluid outlet of the sensor unit, the conditioning fluid inlet and the conditioning fluid outlet positions one on each side of the sensor unit and each positions between the bypass inlet and the bypass outlet,
an internal coupling network comprising fluid paths and one or more flow controls comprising a processor programmed for controlling the flow of fluids in the fluid paths, the internal coupling network configured to operate in each of:
a) an operational mode, where the flow controls of the internal coupling network are configured to allow fluid to flow from the process fluid inlet to the process fluid outlet via a sensor, and
b) a conditioning mode, where the flow controls of the internal coupling network are configured to allow fluid to flow from the conditioning fluid inlet to the conditioning fluid outlet via the sensor or to flow from a calibration fluid inlet to a calibration fluid outlet via the sensor.

4 more elements

Dependencies are inferred from the claim text.

Bioprocessing fluid sensor arrangement

Life of this patent

Bioprocessing fluid sensor arrangement

Life of this patent

Abstract

Claims15