Device for bind and elute chromatography using membranes, and method of manufacture

A bind and elute chromatography unit having an inlet and an outlet, and comprising at least one pair of filter plates interposed between a pair of end plates;

• each of said filter plates of said at least one pair of filter plates comprising a polymeric framework having a filtration zone and one or more membranes bonded to said polymeric framework in said filtration zone wherein said polymeric framework comprises a polyphenylene ether/polystyrene blend wherein said flat filtration zone further comprises a low-shrinkage seal comprising a polystyrene material or a polyphenylene ether/polystyrene blend material, sealing a plurality of stacked membranes;
• the filter plates of said at least one pair of filter plates being placed in back-to-back relation thereby creating a channel between the membrane or membranes in a first plate of said pair and the membrane or membranes in a second plate of said pair, into which fluid flows from said inlet and exits through said outlet after passing through the membrane or membranes in each of said first and second plates, further comprising a plurality of spaced ribs provided within said flat filtration zone to support the plurality of stacked membranes and provide flow passageways to channel fluid towards a plurality of apertures.