Radiotherapies and uses thereof
AssigneeBoard of Regents, The University of Texas System
InventorsJames Welsh, Maria Angelica Cortez, David Hong, Hampartsoum Berj Barsoumian
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Abstract
Provided are methods for sequential radiotherapies, such as XRT. In some embodiments, a higher dosage of an XRT may first be administered to a subject, optionally in combination with an immunotherapy, and subsequently a lower dosage XRT is administered to the subject to treat a cancer. Separating the dosage and intensity of the radiotherapies can be used to achieve improved therapeutic responses, such as improved anti-cancer responses, survival times, and/or abscopal effects.
Claims105
A method of treating a cancer in a mammalian subject comprising:
- administering a first radiotherapy to the subject, wherein the radiotherapy comprises a dose of from about 10 cGy to about 170 cGy per fraction, in combination with:
- a second radiotherapy, wherein the second radiotherapy is a higher dose than the first radiotherapy;
- wherein the first radiotherapy is administered to the subject after the second radiotherapy;
- wherein the second radiotherapy is administered to a primary tumor in the mammalian subject, and
- wherein the first radiotherapy is administered to a secondary tumor or a metastatic tumor in the mammalian subject.
A method of treating a cancer in a mammalian subject comprising:
- administering a first radiotherapy to the subject, wherein the radiotherapy comprises a dose of from about 10 cGy to about 170 cGy per fraction, in combination with:
- a second radiotherapy, wherein the second radiotherapy is a higher dose than the first radiotherapy,
- wherein the second radiotherapy is an external-beam radiation therapy (XRT);
- and wherein the second radiotherapy comprises administering a final dose of from about 50 Gy to about 70 Gy;
- wherein the second radiotherapy is administered to a primary tumor in the mammalian subject, and
- wherein the first radiotherapy is administered to a secondary tumor or a metastatic tumor in the mammalian subject.
A method of treating a cancer in a mammalian subject comprising:
- administering a first radiotherapy to the subject, wherein the radiotherapy comprises a dose of from about 10 cGy to about 170 cGy per fraction, in combination with:
- a second radiotherapy, wherein the second radiotherapy is a higher dose than the first radiotherapy, and
- wherein the first radiotherapy is administered to the subject from about 3 days to about 3 months, or from about 1-4 weeks before the second radiotherapy.
Dependencies are inferred from the claim text.