Methods and systems for target localization and DBS therapy

A medical device configured to optimize a position on an electrode lead implanted in a patient's brain for providing deep brain stimulation (DBS) to the patient's brain, the lead comprising a plurality of electrodes, the device comprising:

• control circuitry configured to:
• (a) determine an optimized stimulation waveform for evoking a detectable evoked potential by:
• using one or more of the electrodes to provide an initial stimulation waveform, and
• adjusting one or more parameters of the initial stimulation waveform until first evoked potentials are detectable using one or more of the electrodes,
• (b) determine an optimized longitudinal stimulation position along an axis of the lead by:
• providing stimulation at different longitudinal positions along the axis of the lead using the optimized stimulation waveform,
• recording second evoked potentials evoked by the stimulation at each of the longitudinal positions,
• comparing the each of the second evoked potentials with each other, and
• selecting the optimized longitudinal stimulation position based on the second evoked potentials, and
• (c) determine an optimized rotational stimulation position about the axis of the lead by:
• at the selected optimized longitudinal stimulation position providing stimulation at different rotational positions about the axis of the lead using the optimized stimulation waveform,
• recording third evoked potentials evoked by the stimulation at each of the rotational positions, and
• selecting the optimized rotational stimulation position based on the third evoked potentials.