System and method for the activation of active ion transporters without the consumption of adenosine triphosphate (ATP) molecules for the treatment of muscle fatigue

A system for controlling active ion transporters for the treatment or prevention of muscle fatigue, the system comprising:

• an electric field generator to generate and apply an oscillating electric field to one or more active ion transporters of one or more muscle tissues, wherein the oscillating electric field comprises three serially applied phases and applying the oscillating electric field comprises;
• applying a synchronization phase to synchronize the active ion transporters to a physiological turnover rate of the active ion transporter down to individual steps within a running cycle with a net-consumption of adenosine triphosphate (ATP) substantially equal to zero, wherein applying the synchronization phase comprises, applying an oscillating electric field to synchronize an ion-pumping in half-cycle and an ion-extrusion half-cycle of the active ion transporters, wherein the ion-pumping in half-cycle of the active ion transporter is in a negative half-cycle and the ion-extrusion half-cycle of the active ion transporter is in a positive half-cycle of the oscillating electric field and wherein applying the synchronization phase further comprises:
• applying an activation overshoot electric pulse at a start of the negative half-cycle and at a start of the positive half-cycle of the oscillating electric field;
• applying an energy-trap overshoot electric pulse at an end of the negative half-cycle and at an end of the positive half-cycle of the oscillating electric field;
• and
• applying an electric field plateau in between the activation overshoot electric pulse and the energy-trap overshoot electric pulse, wherein the activation overshoot electric pulse, the electric field plateau and the energy-trap overshoot electric pulse result in the synchronization of the active ion transporters down to individual steps within the running cycle;
• applying a modulation phase to modulate the synchronized active ion transporters to a predetermined target turnover rate;
• and
• applying a maintenance phase to maintain the synchronized active ion transporters at the predetermined target turnover rate for a predetermined duration of time.

A non-transitory computer-readable medium storing a set of instructions configured for being executed by at least one processor for performing a method for controlling one or more active ion transporters of one or more muscle tissues, the method comprising:

• controlling an electric field generator to apply an oscillating electric field to the one or more active ion transporters, wherein the oscillating electric field comprises three serially applied phases and wherein applying the oscillating electric field comprises;
• applying a synchronization phase to synchronize the active ion transporters to a physiological turnover rate of the active ion transporters down to individual steps within a running cycle with a net-consumption of adenosine triphosphate (ATP) substantially equal to zero, wherein applying the synchronization phase comprises, applying an oscillating electric field to synchronize an ion-pumping in half-cycle and an ion-extrusion half-cycle of the active ion transporters, wherein the ion-pumping in half-cycle of the active ion transporter is in a negative half-cycle and the ion-extrusion half-cycle of the active ion transporter is in a positive half-cycle of the oscillating electric field and wherein applying the synchronization phase further comprises:
• applying an activation overshoot electric pulse at a start of the negative half-cycle and at a start of the positive half-cycle of the oscillating electric field;
• applying an energy-trap overshoot electric pulse at an end of the negative half-cycle and at an end of the positive half-cycle of the oscillating electric field;
• and
• applying an electric field plateau in between the activation overshoot electric pulse and the energy-trap overshoot electric pulse, wherein the activation overshoot electric pulse, the electric field plateau and the energy-trap overshoot electric pulse result in the synchronization of the active ion transporters down to individual steps within the running cycle;
• applying a modulation phase to modulate the synchronized active ion transporters to a predetermined target turnover rate;
• and
• applying a maintenance phase to maintain the synchronized active ion transporters at the predetermined target turnover rate for a predetermined duration of time.