Drug administration method
AssigneeTakeda Pharmaceutical Company Limited
InventorsNaoyuki Murata, Shigeo Yanai
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Abstract
The present disclosure provides a safer novel opening system with highly broad utility for a blood-brain barrier (BBB), the opening system containing a combination of (1) nano-bubble water or nano-bubble aqueous solution containing nano-bubbles having an average diameter of not more than 200 nm, and (2) an ultrasound generating apparatus; a method for opening a BBB, including using the nano-bubble water or nano-bubble aqueous solution, and an ultrasound; and a method for increasing BBB permeability of a drug, including using the nano-bubble water or nano-bubble aqueous solution, and an ultrasound.
Claims20
An opening system for a blood-brain barrier, the system comprising a combination of (a) nano-bubble water or a nano-bubble aqueous solution, said nano-bubble water or said nano-bubble aqueous solution comprising nano-bubbles having an average diameter of not more than 200 nm, and (b) an ultrasound generating apparatus, wherein the nano-bubbles consist of a gas and a non-ionic surfactant.
A method for opening a blood-brain barrier, the method comprising using (a) nano-bubble water or a nano-bubble aqueous solution, said nano-bubble water or said nano-bubble aqueous solution comprising nano-bubbles with an average diameter of not more than 200 nm, and (b) an ultrasound, wherein the nano-bubbles consist of a gas and a non-ionic surfactant.
A method for increasing blood-brain barrier permeability of a drug, the method comprising using (a) nano-bubble water or a nano-bubble aqueous solution, said nano-bubble water or said nano-bubble aqueous solution comprising nano-bubbles with an average diameter of not more than 200 nm, and (b) an ultrasound, wherein the nano-bubbles consist of a gas and a non-ionic surfactant.
Dependencies are inferred from the claim text.