Compositions and materials for regeneration of skeletal muscle
AssigneePurdue Research Foundation
InventorsMeng Deng, Naagarajan Narayanan, Shihuan Kuang
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Abstract
A composition for regeneration of skeletal muscle includes a nerve cell secretome or an isolate thereof. An implantable therapeutic material for regeneration of skeletal muscle includes a hydrogel and nerve cells encapsulated within the hydrogel, wherein at least some of the nerve cells are living. A method of regenerating skeletal muscle includes applying the composition or implanting the implantable material adjacent to skeletal muscle myoblasts and/or myogenic cells to regenerate skeletal muscle therefrom.
Claims17
A medical implant comprising:
- an implantable therapeutic material for regeneration of skeletal muscle comprising
- a hydrogel comprising a reaction product of a composition comprising hyaluronic acid, chondroitin sulfate, and polyethylene glycol or a copolymer thereof, wherein the hydrogel is injectable and has a storage modulus of 10 kPa to 16 kPa, and
- nerve cells encapsulated within the hydrogel, wherein at least some of the nerve cells are living;
- and
- a fiber scaffold in contact with the implantable therapeutic material, wherein the fiber scaffold is an aligned electrospun fiber scaffold that is a fiber mat, and wherein the fiber scaffold comprises skeletal muscle myoblasts and/or myogenic cells.
A method of regenerating skeletal muscle, the method comprising:
- implanting a medical implant adjacent to skeletal muscle myoblasts and/or myogenic cells to regenerate skeletal muscle therefrom, the medical implant comprising
- an implantable therapeutic material for the regeneration of skeletal muscle comprising a hydrogel and nerve cells encapsulated within the hydrogel, wherein at least some of the nerve cells are living, wherein the nerve cells encapsulated within the hydrogel release a nerve cell secretome such that the hydrogel releases the secretome, and wherein the hydrogel is injectable and has a storage modulus of 10 kPa to 16 kPa, and
- a fiber scaffold in contact with the implantable therapeutic material, wherein the fiber scaffold is an aligned electrospun fiber scaffold that is a fiber mat.
Dependencies are inferred from the claim text.