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US 12,178,942 B2Granted
Method for manufacturing stent for drug release, including flexible nanostructured film connected in three dimensions, and stent for drug release prepared thereby
AssigneeKorea Institute of Science and Technology
InventorsJoonseok Lee, Eunyoung Jeon
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Abstract
Provided are a method of manufacturing a stent for drug release that may be coated with a drug by forming a 3D nanostructured film on the surface of a stent and a stent for drug release manufactured thereby, more particularly, a method of manufacturing a stent for drug release including: (a) preparing a stent, (b) forming a 3D nanostructured film on a surface of the stent; and (c) surface-treating the 3D nanostructured film, and a stent for drug release manufactured thereby.
Claims15
A method of manufacturing a stent for drug release, the method comprising:
- (a) preparing a stent;
- (b) forming a three-dimensional (3D) nanostructured film on a surface of the stent, wherein step (b) comprises (b1) adding an ionic surfactant and an auxiliary spacer to a reactor in which the stent is immersed, and stirring and heating a mixture, (b2) adding a ceramic precursor solution to the reactor, and stirring and heating the mixture, and (b3) removing residual substances by washing the stent;
- and
- (c) surface-treating the 3D nanostructured film,
- wherein the ionic surfactant is a cationic surfactant or an anionic surfactant,
- wherein when the cationic surfactant is present, the auxiliary spacer comprises at least one selected from the group consisting of sodium salicylate, sodium benzoate, sodium cinnamate, salicylic acid, benzoic acid, cinnamic acid, sodium methoxybenzoate, methoxybenzoic acid, sodium vinylbenzoate, vinylbenzoic acid, and sodium p-toluenesulfonate.
3 more elements
Dependencies are inferred from the claim text.