Compositions and treatment procedures for the treatment of pathogenic infections

A pharmaceutical composition comprising:

• an essentially solid solvent-free composition, said essentially solid solvent-free composition comprising:
• one or more oxidising components selected from the group consisting of:
• sodium hypochlorite and potassium hypochlorite,
• wherein said one or more oxidising components are dispersible or soluble in an aqueous liquid medium,
• wherein dispersal or dissolution of said one or more oxidising components in an aqueous medium comprising at least one dispersible or soluble solid solvent-free acid component, being provided in conjunction or in combination with said one or more oxidising components comprised in the solid solvent-free composition, results in the release or generation of a molecular or ionic chlorine dioxide or a derivative thereof as an active agent within the respective aqueous liquid medium,
• wherein said essentially solid solvent-free composition comprises an absorbable therapeutically effective non-toxic amount of said one or more oxidising components absorbable by transit through the buccal cavity of a warm-blooded mammalian subject,
• wherein said one or more oxidising components are intimately admixed with at least one dispersible or soluble solid solvent-free acid component selected from the group consisting of:
• anhydrous citric acid,
• wherein an amount of an alkali metal carbonate or bicarbonate salt is provided in conjunction with the solid solvent-free composition, and
• wherein said pharmaceutical composition is provided as oral dosage form in a soluble sublingual dosage form, adapted to be retained in the mouth or buccal cavity by the warm-blooded mammalian subject and thereby allowing for a sublingual release of said one or more oxidising component within an acidic aqueous medium provided by simultaneous sublingual release of said at least one dispersible or soluble solid solvent-free acid component into salivary contents of the buccal cavity and thereby enabling direct systemic absorption of the active agent by absorption sites offered by the sublingual surfaces of the lining of the buccal cavity of the warm-blooded mammalian subject,
• wherein the composition comprises a proportion of sodium bicarbonate or potassium bicarbonate or a combination thereof, which is in excess of about 30% w/w of the total weight of the composition, and
• wherein a proportion of the one or more oxidising component in the pharmaceutical composition is selected to provide a concentration of the one or more oxidising component within the aqueous medium available in a selected body cavity of the mammalian subject that is greater than about 10 ppm and less than about 100 ppm.