High concentration formulations of anti-CSF1 and anti-CSF1R antibodies
AssigneeAmMax Bio, Inc.
InventorsLaman Alani, Chung-Chiang Hsu, Aihua Zhu, Kirk William Johnson, Michael Huang
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Abstract
Provided are high concentration stable formulations of anti-CSF1R/CSF1 antibodies. An example formulation includes 105 to 250 mg/mL of the antibody, 100 mM to 200 mM of arginine glutamate or arginine HCl, 10 mM to 50 mM histidine, and 0.015 to 0.035 w/v % of polysorbate 80, at a pH of 5.4 to 5.6. Also provided are methods of using the formulations for treating diseases.
Claims10
An aqueous pharmaceutical composition comprising at least 105 mg/mL of an antibody, a salt of arginine selected from the group consisting of arginine glutamate, arginine aspartate, and arginine HCl, histidine, and polysorbate (PS) selected from the group consisting of PS 80 and PS 20, at a pH of 5.0-6.0, wherein the antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO:7 and a light chain comprising the amino acid sequence of SEQ ID NO:8.
Dependencies are inferred from the claim text.