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US 12,178,908 B2Granted
Tolerogenic liposomes and methods of use thereof
AssigneeAnTolRx, Inc.
InventorsAditi Jhaveri, Vincent P. Stanton, Jr.
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Abstract
The invention provides compositions (e.g., liposomes) for treating diseases and conditions associated with pathologic immune responses and methods for formulating and administering such compositions.
Claims9
A composition comprising a population of liposomes having an average diameter from 50 to 250 nanometers (nm), wherein the population of liposomes comprises:
- (i) a lipid mixture comprising (a) at least 50% of egg phosphatidylcholine or 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC);
- (b) between 26 mole percentage and 34 mole percentage cholesterol;
- and (c) a saturated poly(ethylene glycol) (PEG) derivatized lipid;
- (ii) an average from 200-15,000 molecules of 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester (ITE), or salt thereof, per liposome.
1 more element
Dependencies are inferred from the claim text.