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US 12,178,907 B2Granted
Binary lipid bilayer-containing vesicles comprising embedded cytotoxic agents and methods of making and using the same
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsAnu Puri, Mathias Viard
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Abstract
Embodiments of vesicles comprising embedded cytotoxic agents are disclosed, as well as methods of making and using the vesicles. Pharmaceutical compositions including the vesicles also are disclosed. The vesicles include a binary lipid bilayer surrounding a cavity, wherein the vesicle binary lipid bilayer includes (i) a non-bilayer forming lipid (or combination of non-bilayer forming lipids) and a PEGylated lipid; and (i) a cytotoxic agent embedded within the vesicle wall.
Claims27
A vesicle, comprising:
- a binary lipid bilayer comprising an alkyne-containing phospholipid and a PEGylated lipid;
- and
- a cytotoxic agent embedded in the binary lipid bilayer;
- wherein the binary lipid bilayer is free of, or does not comprise, a lipid other than the alkyne-containing phospholipid or the PEGylated lipid.
1 more element
A vesicle, comprising:
- a binary lipid bilayer comprising (i) DSPE-PEG2000 and (ii) DC8,9PC, or a combination of DC8,9PC and DC8,9PE;
- and
- HPPH, Ce6, and/or camptothecin embedded in the binary lipid bilayer;
- and wherein the binary lipid bilayer is free of, or does not comprise, a lipid other than the DC8,9PC, the DC8,9PE, and the DSPE-PEG2000.
1 more element
Dependencies are inferred from the claim text.