US 12,178,902 B1 · Methods and compositions for fluid drainage by Piezo ion channel activation

Abstract

A method of treating impaired lymphatic function in a subject is provided. The method includes a step of inducing activation of Piezo1 ion channels in lymphatic tissues of a subject having impaired lymphatic function. Similarly, a method of treating ocular hypertension or glaucoma in a subject includes a step of inducing activation of Piezo1 ion channels in an eye of a subject having an ocular pressure that is greater than 22 mm Hg. Finally, a method of treating ocular hypertension or glaucoma in a subject includes a step of inducing activation of Piezo1 ion channels in an eye of a subject having an ocular pressure that is greater than 22 mm Hg.

Claims12

Dependent claims

A method of treating impaired lymphatic function in a subject, the method comprising the step of:

administering a pharmaceutical composition to the subject having dysfunctional lymphatic valves in lymphatic tissues to treat the dysfunctional lymphatic valves in the lymphatic tissues, wherein the pharmaceutical composition includes a Piezo1 agonist that is 2-[(2,6-dichlorophenyl)methylsulfanyl]-5-pyrazin-2-yl-1,3,4-thiadiazole, wherein administration of the pharmaceutical composition is in a sufficient amount to enhance expression of lymphatic valve-associated genes FOXC2, GATA2, CX37, and LAMA5 through Piezo1-dependent pathways, and to promote expression of ITGA9 through Piezo1-independent pathways, thereby promoting formation and function of lymphatic valves.

Dependencies are inferred from the claim text.

Facts

Application

17/146,935Filed 12 Jan 2021 · us provisional application

Priority

12 Jan 2020

Granted

31 Dec 2024

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

A61K 9/0009
Galenical forms characterised by the drug release technique; Application systems commanded by energy: involving or responsive to electricity,…
A61K 9/0048
Galenical forms characterised by the site of application: eye, e.g. artificial tears
A61K 31/497
Non-condensed pyrazines: containing further heterocyclic rings
A61K 41/0047
Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations: sonopheresis,…

Methods and compositions for fluid drainage by Piezo ion channel activation

Life of this patent

Methods and compositions for fluid drainage by Piezo ion channel activation

Life of this patent

Abstract

Claims12