Pharmaceutical compositions

A method for preparing a homogeneous, stable liposomal hydrogel comprising the steps of:

• a) dispersing dried phospholipids at room temperature in a first aqueous solution to obtain phospholipid colloids;
• b) dispersing separately hyaluronic acid at room temperature in a second aqueous solution, wherein the hyaluronic acid is a mixture of low molecular, medium molecular, and high molecular weight hyaluronic acid;
• c) liquifying 7-dehydrocholesterol (7-DHC) at a temperature between 14° and 150° C.;
• d) adding an organic solvent to the liquified 7-DHC obtained in step c) to obtain a mixture;
• e) admixing the mixture obtained in step d) to the phospholipid colloids obtained in step a) under stirring at room temperature to obtain colloidal spheres of 20-150 nm;
• f) adding the dispersed hyaluronic acid obtained in step b) to the colloidal spheres of step e) to obtain a further mixture;
• and
• g) continue stirring the further mixture at room temperature to obtain a homogeneous, stable liposomal hydrogel comprising the 7-DHC and the mixture of hyaluronic acids encapsulated in phospholipid colloids.