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US 12,178,886 B2Granted
Imaging and treatment of pathophysiologic conditions by Cerenkov radiation
AssigneeWashington University
InventorsSamuel Achilefu, Nalinikanth Kotagiri
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Abstract
The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (CRIT).
Claims19
A composition, comprising a photoinitiator, one or more photosensitizers and a targeting agent, wherein the photoinitiator is titanocene or titanocene dichloride and the targeting agent is albumin.
A method for treating a cancer or tumor in a subject in need thereof, the method comprising:
- a) administering to the subject a composition comprising a photoinitiator and a targeting agent, wherein the photoinitiator is titanocene or titanocene dichloride and the targeting agent is albumin;
- and
- b) administering concurrently or subsequently to the subject a composition comprising an amount of a radionuclide effective to activate the composition in step a), thereby treating the cancer or tumor.
A composition, comprising a photoinitiator, at least one radionuclide and a targeting agent, wherein the photoinitiator is titanocene or titanocene dichloride and the targeting agent is albumin.
Dependencies are inferred from the claim text.