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US 12,178,879 B2Granted
Hemiasterlin derivative and antibody-drug conjugate thereof
AssigneeSumitomo Pharma Co., Ltd.
InventorsHitoshi Ban, Atsushi Suwa
Life of this patent
Estimating the term…
Abstract
A compound represented by formula (1): wherein R1 represents a hydrogen atom or a sulfonyl group; and Z represents a group represented by formula (Z-1), or a salt thereof.
Claims14
A compound represented by formula (1):
- wherein
- R1 represents a hydrogen atom or a sulfonyl group;
- and
- Z represents a group represented by formula (Z-1), formula (Z-2) or formula (Z-3):
- where
- W represents a group represented by formula (W-1):
- where
- Q represents a group represented by formula (Q-1) or formula (Q-2):
- R2 represents —(CH2)u—COOH;
- and
- u represents 1 or 2,
- or a salt thereof.
9 more elements
An antibody-drug conjugate represented by formula (2):
- wherein
- mAb represents an antibody;
- q represents an integer of 1 to 30;
- and
- Z represents a group represented by formula (Z-1), formula (Z-2) or formula (Z-3):
- where
- W represents a group represented by formula (W-1):
- where
- Q represents a group represented by formula (Q-1) or formula (Q-2):
- R2 represents —(CH2)u—COOH;
- and
- u represents 1 or 2,
- or a pharmaceutically acceptable salt thereof.
10 more elements
Dependencies are inferred from the claim text.