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US 12,178,873 B2Granted
High concentration antibody formulations
AssigneeAmgen Inc.
InventorTimothy David Osslund
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Abstract
Discloses herein are high concentration antibody thrmulations comprising an anti-sclerostin immunoglobulin and an acetate salt and/or an acetate buffer and methods of use.
Claims10
A sterile liquid formulation comprising:
- (a) an anti-sclerostin immunoglobulin at a concentration of from about 70 mg/mL to about 120 mg/mL, wherein the immunoglobulin comprises a set of 6 CDRS set forth in amino acid sequences SEQ ID NOs:
- 73-78;
- (b) calcium acetate, wherein the calcium acetate comprises calcium at a concentration ranging from about 5 mM to about 15 mM;
- and acetate at a concentration ranging from about 10 mM to about 90 mM;
- and
- (c) a polyol in an amount ranging from about 4% w/v to about 6% w/v.
3 more elements
Dependencies are inferred from the claim text.