Compositions and methods for treating diseases associated with an imprinting defect
AssigneeChildren's Medical Center Corporation
InventorsYi Zhang, Azusa Inoue
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Abstract
The invention provides methods for activating a repressed allele within an imprinting control region, thereby treating an imprinting associated disorder.
Claims6
A method of activating a histone H3 lysine 27 trimethylation (H3K27me3) repressed allele within an imprinting control region of a H3K27me3-dependent, paternally- or maternally-expressed imprinted gene in a non-human mammalian zygote or preimplantation embryo, the method comprising contacting the non-human, mammalian zygote or preimplantation embryo with a small molecule inhibitor of H3K27 methyltransferase to inhibit histone H3 lysine 27 trimethylation;
- wherein the H3 lysine 27 trimethylation mediates imprinting of the gene and the inhibitor relieves H3K27me3-dependent imprinting within the imprinting control region of the gene.
Dependencies are inferred from the claim text.