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US 12,178,847 B2Granted
Compositions and methods for adjoining type I and type II extracellular domains as heterologous chimeric proteins
AssigneeKopfkino IP, LLC
InventorsTaylor Schreiber, George Fromm, Suresh De Silva, Neal Schilling
Life of this patent
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Abstract
The present invention relates to, inter alia, compositions and methods, including chimeric proteins that find use in the treatment of disease, such as immunotherapies for cancer and autoimmunity. In part, the invention provides, in various embodiments, fusions of extracellular domains of transmembrane proteins that can have stimulatory or inhibitory effects.
Claims18
A heterologous chimeric protein comprising:
- (a) a first domain comprising an extracellular domain of human programmed cell death protein 1 (PD-1) that is capable of binding a PD-1 ligand, and comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:
- 32;
- (b) a second domain comprising an extracellular domain of human glucocorticoid-induced TNFR-related (GITR) ligand (GITRL) that is capable of binding a GITRL receptor;
- and
- (c) a linker linking the first domain and the second domain and comprising a hinge-CH2-CH3Fc domain, wherein the linker comprises an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:
- 71 or SEQ ID NO:
- 72.
4 more elements
A recombinant fusion protein comprising:
- (a) a first domain comprising an extracellular domain of human programmed cell death 1 (PD-1) that is at least 95% identical to the amino acid sequence of SEQ ID NO:
- 32 and is capable of binding a PD-1 ligand,
- (b) a second domain comprising an extracellular domain of human glucocorticoid-induced TNFR-related (GITR) ligand (GITRL) and is capable of binding a GITRL receptor, and
- (c) a linker linking the first domain and the second domain, wherein the linker comprises an amino acid sequence that is at least 95% identical to SEQ ID NO:
- 71 or SEQ ID NO:
- 72.
3 more elements
Dependencies are inferred from the claim text.