Methods and compositions relating to the treatment of tumors
AssigneeThe General Hospital Corporation
InventorsGary J. Brenner, Giulia Fulci, Sherif Ahmed
Life of this patent
Estimating the term…
Abstract
Described herein are methods and compositions relating to the treatment of a tumor (e.g., schwannoma) by increasing expression of Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D. In some embodiment, the increased expression is provided by means of a vector or construct comprising a nucleic acid encoding Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D operably linked to a Schwann-lineage cell-specific promoter. In some embodiments, the vector is a viral vector.
Claims21
A method of treating a schwannoma in a subject in need thereof, the method comprising:
- administering a viral vector comprising a nucleic acid encoding Apoptosis-associated Speck-like protein containing a CARD (ASC) operably linked to a Schwann cell-specific promoter;
- and
- wherein the subject is not administered a viral vector comprising a caspase gene.
Dependencies are inferred from the claim text.