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US 12,178,840 B2Granted
Method and compositions comprising a CT20 peptide
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorsAnnette Khaled, Jesus Manuel Perez, Rania Bassiouni
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Abstract
Disclosed herein are compositions comprising a CT20 peptide and methods of using the disclosed compositions to treat cancers expressing chaperonin containing TCP (CCT).
Claims13
A method of treating a subject having lung cancer, the method comprising:
- obtaining a lung tumor tissue sample from the subject;
- measuring the amount of chaperonin containing TCP (CCTβ) in the lung tumor tissue sample using immunohistochemical staining;
- assigning a score to the lung tumor tissue sample based on immunohistochemical staining intensity, wherein a score of 0 indicates no immunohistochemical staining for CCTβ, a score of 1 indicates faint, focal cytoplasmic immunohistochemical staining for CCTβ, a score of 2 indicates weak cytoplasmic immunohistochemical staining for CCTβ throughout the lung tumor tissue sample, a score of 3 indicates intense immunohistochemical staining for CCTβ that does not obscure cell nuclei, and a score of 4 indicates intense immunohistochemical staining for CCTβ that obscures cell nuclei;
- and
- initiating a therapeutic regimen if the score of the lung tumor tissue sample is 1 or greater, wherein the therapeutic regimen comprises administering to the subject an effective amount of a composition comprising a CT20 peptide, and wherein the CT20 peptide comprises the amino acid sequence of SEQ ID NO:
- 1.
3 more elements
Dependencies are inferred from the claim text.