Methods of treating hematological malignancies using 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dion

A method of treating a hematological malignancy, comprising administering to a subject in need thereof a therapeutically effective amount of Compound 1 of the formula:

• or a tautomer, isotopolog, or pharmaceutically acceptable salt thereof, in one or more 7-day, 14-day, or 28-day treatment cycles, and wherein the hematological malignancy is marginal zone lymphoma (MZL), Burkitt lymphoma (BL), multiple myeloma (MM), myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), T-cell lymphoma (TCL), or Hodgkin's lymphoma (HL).