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US 12,178,809 B2Granted
Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof
AssigneeBoehringer Ingelheim International GmbH
InventorsJoerg P. Hehn, Andreas Blum, Oliver Hucke, Stefan Peters
Life of this patent
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Abstract
The invention relates to new pyridinyl sulfonamide derivatives of the formula wherein R1, A and n are as defined herein, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
Claims26
A compound of formula (I)
- wherein
- ring A is selected from the group consisting of:
- R1 is selected from the group consisting of H, F, Cl, Br, CN, —OH, C1-4-alkyl, alkyl), —(CH2)m—COOH, —(CH2)m—C(═O)—O—(C1-4-alkyl), —C(═O)-heterocyclyl, —(CH2)m—C(═O)—NH2, —(CH2)m—C(═O)—NH—(C1-4-alkyl), —(CH2)m—C(═O)—N(C1-4-alkyl)2, —C(═O)—NH—C3-6-cycloalkyl, —C(═O)—NH-heterocyclyl, —(CH2)m—NH—C(═O)—(C1-3-alkyl), —N(C1-3-alkyl)-C(═O)—(C1-4-alkyl), —N(C1-3-alkyl)-C(═O)—NH2, —NH—C(═O)—NH—(C1-4-alkyl), heterocyclyl and phenyl,
- wherein each alkyl group or sub-group is optionally substituted with 1 or more F atoms or with one OH or —O—(C1-3-alkyl) group;
- and
- wherein each heterocyclyl is selected from the group consisting of azetidinyl, imidazolidinyl, piperidinylpiperidinyl, tetrahydropyranyl and morpholinyl, and each heterocycl is optionally substituted with one or two groups independently selected from the group consisting of oxo, C1-3-alkyl, —C(═O)—CH3 and —C(═O)-cyclopropyl;
- and
- wherein multiple R1 may be identical or different, if n is 2;
- and
- n is an integer selected from 1 and 2;
- and
- m is an integer selected from 0, 1 and 2;
- and
- wherein in any definition mentioned hereinbefore, if not specified otherwise, any alkyl group or sub-group may be straight-chained or branched and is optionally substituted with 1 or more F atoms,
- or a salt thereof.
12 more elements
Dependencies are inferred from the claim text.