Amorphous solid dispersion comprising 6-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide
AssigneeBeijing Innocare Pharma Tech Co., Ltd.
InventorsXiangyang Chen, Zuopeng Wang, Liqin Yu
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Abstract
The present invention relates to an amorphous solid dispersion comprises 6-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide (Compound I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable polymer. The present invention also relates to pharmaceutical compositions comprising the amorphous solid dispersion. The amorphous solid dispersion of the present invention is stable upon storage and provides a better dissolution rate and bioavailability when comparing with a crystalline form.
Claims6
An amorphous solid dispersion comprising 20-40% w/w of compound I or a pharmaceutically acceptable salt thereof, and 60-80% w/w of hydroxypropylmethylcellulose-acetate succinate (HPMC-AS),
Dependencies are inferred from the claim text.