US 12,178,804 B2 · Salts of cycloserine compounds and applications thereof

Abstract

Provided herein is salts of formula [A][B], wherein [A] is a cation form of a cycloserine compound and [B] is an anion form of a compound of Formula (I), wherein the ratio between the cycloserine compound and the compound of formula (I) ranges from 10:1 to 1:10. The salts described herein have improved properties, including greatly increased stability and decreased hygroscopicity. Also provided herein are methods for treating and/or reducing the risk of a neuropsychiatric disorder and/or a bacterial infectious disease (e.g., tuberculosis), comprising administering a subject in need a composition comprising salts of formula [A][B] described herein.

Claims15

Dependent claims

A method for treating a neuropsychiatric disorder or a bacterial infectious disease, the method comprising administering an effective amount of a salt of formula [A] [B] to a subject in need thereof, wherein [A] is a cation form of a cycloserine compound;

and [B] is an anion form of a compound of formula (I):
in which
X is —NH2 or —OH;
each of L1 and L2, independently, is C1-6 alkylene, C2-6 alkenylene, or C2-6 alkynylene, or one of L1 and L2 is N, O, or S, and the other one is C1-6 alkylene, C2-6 alkenylene, or C2-6 alkynylene, as valency permits;
is either a single or double bond;
and
wherein the ratio of [A] and [B] in the salt ranges from 10:1 to 1:10.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

17/275,794Filed 12 Sep 2019 · continuation in part

Priority

13 Sep 2018

Published

US 2022/0047561 A117 Feb 2022

Granted

31 Dec 2024

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61K 31/42
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: oxazoles
A23L 33/10
Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof: using additives
A23L 33/135
Using additives: bacteria or derivatives thereof, e.g. probiotics
A61K 31/194
Carboxylic acids, e.g. valproic acid: having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid

Salts of cycloserine compounds and applications thereof

Life of this patent

Salts of cycloserine compounds and applications thereof

Life of this patent

Abstract

Claims15