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US 12,178,796 B2Granted
Drug-loaded nanofiber membrane, method for preparing the same, and application thereof
AssigneeShenzhen Guangyuan Biomaterial Co., Ltd.
InventorsZhichao Han, Shanshan Xu, Jia'en Wu
Life of this patent
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Abstract
A drug-loaded nanofiber membrane includes a first fiber, a second fiber, and a drug. The drug is dispersed into the first fiber. The first fiber includes poly(lactic-co-glycolic acid) copolymer (PLGA copolymer), and the second fiber includes poly(p-dioxanone) (PDO).
Claims9
A drug-loaded nanofiber membrane comprising a first fiber and a second fiber;
- the first fiber comprises poly(lactic-co-glycolic acid) copolymer (PLGA copolymer) and a drug dispersed within the first fiber, and the second fiber comprises poly(p-dioxanone) (PDO);
- wherein:
- the PLGA copolymer is a mixture consisting of a high-molecular weight PLGA copolymer and a low-molecular weight PLGA copolymer;
- the high-molecular weight refers to a viscosity-average molecular weight of 100,000 to 150,000 Da, and the low-molecular weight refers to a viscosity-average molecular weight of 40,000 to 80,000 Da;
- a mass ratio of the high-molecular weight PLGA copolymer to the low-molecular weight PLGA copolymer is between 25:75 and 3:97;
- and
- a total mass of the second fiber accounts for 1%-25% of a total mass of the first fiber.
4 more elements
A drug-loaded nanofiber membrane comprising a first fiber, a second fiber, and a drug dispersed into the first fiber;
- the first fiber comprising poly(lactic-co-glycolic acid) copolymer (PLGA copolymer), and the second fiber comprising poly(p-dioxanone) (PDO);
- wherein:
- the PLGA copolymer is a mixture of a high-molecular weight PLGA copolymer and a low-molecular weight PLGA copolymer;
- the high-molecular weight refers to a viscosity-average molecular weight of 100,000 to 150,000 Da, and the low-molecular weight refers to a viscosity-average molecular weight of 60,000 to 80,000 Da;
- a mass ratio of the high-molecular weight PLGA copolymer to the low-molecular weight PLGA copolymer is between 25:75 and 3:97;
- and
- a total mass of the second fiber accounts for 1%-25% of a total mass of the first fiber.
4 more elements
Dependencies are inferred from the claim text.