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AssigneeSichuan Jiuzhang Biological Science and Technology Co., Ltd.
InventorsJie Zhang, Xiaoguang Chen, Huarong Yang, Wang Huang
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A pharmaceutical composition includes chlorogenic acid and coumaroylquinic acid. It can be used for preparing a reversing agent for tumor multi-drug resistance and a PD-1/PD-L1 inhibitor. The combined use of chlorogenic acid and coumaroylquinic acid exhibits a synergistic effect, effectuating a good reversing effect on the drug resistance of a tumor cell strain that produces multi-drug resistance for chemotherapeutic drugs and immunotherapeutic drugs, which may effectively inhibit PD-1/PD-L1 expression in drug-resistant B16 melanoma and drug-resistant Lewis lung cancer mice transplantation tumor tissue, and may effectively proliferate CD4+T and CD8+T cells in drug-resistant B16 melanoma mice and Lewis lung cancer mice.
A method for treating multidrug resistance to a tumor, comprising administering to a subject in need thereof a reversal agent, wherein the reversal agent comprises chlorogenic acid and a coumaroylquinic acid at a mass ratio of chlorogenic acid to coumaroylquinic acid of 100:0.01 to 100:0.5, wherein said tumor is melanoma or lung cancer, and is resistant to dacarbazine, gemcitabine, or nivolumab.
A method for treating a tumor, comprising:
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