Full depth laser ophthalmic surgical system, methods of calibrating the surgical system and treatment methods using the same

A full depth ophthalmic surgical system for performing surgery on an eye of a subject, comprising:

• a femtosecond laser source configured to produce a femtosecond pulsed laser beam;
• an imaging assembly configured to emit an imaging beam;
• a scanning assembly including a Z scanner and an XY scanner, configured to scan a focal spot of the laser beam and the imaging beam within the eye in a depth direction and two transverse directions, respectively;
• an illumination light source configured to emit an illumination light;
• a video camera assembly, including a detector and a tunable lens in front of the detector;
• an objective lens assembly configured to focus the laser beam and the imaging beam;
• a patient interface configured to be coupled to the objective lens assembly and to engage the eye, the patient interface including a lens having a predefined optical power;
• and
• optical components including at least one beam splitter, configured to direct the laser beam and the imaging beam output by the scanning assembly and the illumination light to the objective lens assembly, and to direct light emitted from within the eye, which has passed through the objective lens assembly, to the video camera assembly;
• wherein the scanning assembly, the objective lens assembly and the lens of the patient interface are configured to form the focal spot of the laser beam at any and all depths within a range of 15 mm to 24 mm in water beyond a distal surface of the lens of the patient interface, and
• wherein the tunable lens is configured to cooperate with the objective lens assembly and the lens of the patient interface to focus light emitted from any and all distances within a range of 8 mm to 29 mm in water beyond the distal surface of the lens of the patient interface onto the detector to produce images of any and all tissues of the eye from an iris to a retina, including regions of a vitreous humor, on the detector.