Patient state determination based on one or more spectral characteristics of a bioelectrical brain signal

A system comprising:

• a memory that stores biomarker information;
• and
• one or more processors configured to:
• select a frequency band of interest of a bioelectrical brain signal of a patient, wherein the selected frequency band of interest includes a beta band;
• after selecting the frequency band of interest, select two or more frequency sub-bands from a plurality of frequency sub-bands of the selected frequency band of interest;
• determine the bioelectrical brain signal includes a biomarker indicative of a patient state based on the stored biomarker information, wherein the stored biomarker information includes one or more spectral characteristics of the selected two or more frequency sub-bands of the selected frequency band of interest,
• wherein a first frequency sub-band of the selected two or more frequency sub-bands of the selected frequency band of interest includes higher frequencies of the beta band relative to a second frequency sub-band of the selected two or more frequency sub-bands of the selected frequency band of interest, and
• wherein to determine the bioelectrical brain signal includes the biomarker based on the stored biomarker information including one or more spectral characteristics, the one or more processors are configured to determine whether a dominant amount of beta band activity is in the first frequency sub-band or the second frequency sub-band;
• and
• control a medical device to deliver therapy to the patient based on determining that the bioelectrical brain signal includes the biomarker indicative of the patient state.

A non-transitory computer readable storage medium comprising instructions that, when executed by one or more processors, cause the one or more processors to:

• select a frequency band of interest of a bioelectrical brain signal of a patient, wherein the selected frequency band of interest includes a beta band;
• after selecting the frequency band of interest, select two or more frequency sub-bands from a plurality of frequency sub-bands of the selected frequency band of interest;
• determine the bioelectrical brain signal includes a biomarker indicative of a patient state based on stored biomarker information including one or more spectral characteristics of the selected two or more frequency sub-bands of the selected frequency band of interest,
• wherein a first frequency sub-band of the selected two or more frequency sub-bands of the selected frequency band of interest includes higher frequencies of the beta band relative to a second frequency sub-band of the selected two or more frequency sub-bands of the selected frequency band of interest, and
• wherein the instructions that cause the one or more processors to determine the bioelectrical brain signal includes the biomarker based on the stored biomarker information including one or more spectral characteristics includes instructions that cause the one or more processors to determine whether a dominant amount of beta band activity is in the first frequency sub-band or the second frequency sub-band;
• and
• control therapy delivery by a medical device to the patient based on determining that the bioelectrical brain signal includes the biomarker indicative of the patient state.