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US 12,178,595 B2Granted
Methods and apparatus for intraoperative assessment of parathyroid gland vascularity using laser speckle contrast imaging and applications of same
AssigneeVanderbilt University
InventorsEmmanuel A. Mannoh, Anita Mahadevan-Jansen
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Abstract
One aspect of the invention relates to a method for intraoperative detection of parathyroid gland viability in a surgery, comprising obtaining speckle contrast images of a parathyroid gland of a patent; and displaying the speckle contrast images of the parathyroid gland in real-time.
Claims10
A method for intraoperatively providing anatomical guidance in an endocrine surgery, comprising:
- obtaining speckle contrast images of a parathyroid gland of a patient;
- and
- displaying the speckle contrast images of the parathyroid gland in real-time,
- wherein said obtaining the speckle contrast images of the parathyroid gland of the patient comprises:
- diffusing a beam of light onto a tissue surface of a parathyroid gland of the patient to illuminate the tissue surface;
- acquiring images of the illuminated tissue surface, wherein each of the acquired images comprises a speckle pattern;
- and
- processing the acquired images to obtain speckle contrast images, wherein said processing the acquired images comprises calculating a plurality of speckle contrasts from the acquired images of the parathyroid gland to obtain a resultant speckle contrast image, wherein the resultant speckle contrast image has values that range from 0 to 1 with values closer to 0 representing regions of greater motion (perfusion) and 1 representing regions with no motion.
5 more elements
An apparatus for intraoperatively providing anatomical guidance in an endocrine surgery, comprising:
- a means for obtaining speckle contrast images of a parathyroid gland of a patient;
- and
- a display for displaying the speckle contrast images of the parathyroid gland in real-time,
- wherein said means for obtaining the speckle contrast images comprises:
- a light source for emitting a beam of light that is diffused onto a tissue surface of the parathyroid gland of the patient to illuminate the tissue surface;
- a detector for acquiring images of the illuminated tissue surface;
- and
- a controller arranged to operate the detector to acquire the images of the illuminated tissue surface, receive the acquired images from the detector, and process the acquired images to obtain the speckle contrast images;
- wherein said processing the acquired images comprises calculating a plurality of speckle contrasts from the acquired images of the parathyroid gland to obtain a resultant speckle contrast image, wherein the resultant speckle contrast image has values that range from 0 to 1 with values closer to 0 representing regions of greater motion (perfusion) and 1 representing regions with no motion.
6 more elements
Dependencies are inferred from the claim text.