System and method for generating a sensorial stimulus

A system for training a subject to reinforce self-modulation of pain pathways, the system comprising:

• an acquisition set-up for acquiring at least two electroencephalographic signals from the subject;
• a data processing system for carrying out a method comprising:
• a) receiving the electroencephalographic data comprising at least two electroencephalographic signals measured simultaneously from at least two electroencephalogram channels;
• b) filtering the at least two electroencephalographic signals with a band-pass filter that only passes alpha waves;
• c) computing an averaged signal of the at least two filtered electroencephalographic signals;
• d) computing an alpha phase synchrony neuromarker as a Frobenius squared norm a of the averaged signal on a temporal window;
• and
• e) generating a sensorial stimulus representing the alpha phase synchrony neuromarker;
• and
• an output generator, by which the data processing system generates the sensorial stimulus, which reports to the subject said sensorial stimulus representing a numerical value of the alpha phase synchrony neuromarker, wherein said sensorial stimulus is selected from the group consisting of:
• visual stimulus and auditory stimulus, said output generator being selected among:
• lights, LEDS, a screen, a smartphone, a computer monitor, a television, or a head-mounted display.

A non-transitory computer-readable storage medium comprising instructions which, when the program is executed by a computer, cause the computer to carry out a computer-implemented method for training a subject to reinforce self-modulation of pain pathways using electroencephalographic data acquired from the brain of said subject, said method comprising:

• a) receiving the electroencephalographic data comprising at least two electroencephalographic signals measured simultaneously from at least two electroencephalogram channels;
• b) filtering the at least two electroencephalographic signals with a band-pass filter that only passes alpha waves;
• c) computing an averaged signal of the at least two filtered electroencephalographic signals;
• d) computing an alpha phase synchrony neuromarker as a Frobenius squared norm a of the averaged signal on a temporal window;
• e) generating a sensorial stimulus representing the alpha phase synchrony neuromarker, wherein said sensorial stimulus is selected from the group consisting of:
• visual stimulus and auditory stimulus;
• and
• f) training the subject to reinforce self-modulation of pain pathways with the generated sensorial stimulus, by reporting said sensorial stimulus to the subject using an output generator, said output generator being selected among:
• lights, LEDS, a screen, a smartphone, a computer monitor, a television, or a head-mounted display.