Systems and methods for imaging a body region using implanted markers

A system for localization of a region within a patient's body, the system comprising:

• a plurality of markers configured and sized for implantation within a region of a patient's body;
• a probe comprising:
• a transmit antenna for transmitting electromagnetic signals into a patient's body;
• a receive antenna for receiving reflected signals from the plurality of markers configured to be implanted within the patient's body;
• an antenna placement template comprising a plurality of apertures sized to receive a distal end of the probe, each aperture positioned at a known location relative to each other aperture;
• and
• one or more processors coupled to the probe, the one or more processors configured to:
• process a first set of modulated reflected signals from the plurality of markers when the probe is placed in a first aperture of the plurality of apertures to determine a first set of distance values corresponding to distances from each of the plurality of markers to the distal end of the probe when in the first aperture;
• process a second set of modulated reflected signals from the plurality of markers when the probe is placed in a second aperture of the plurality of apertures to determine a second set of distance values corresponding to distances from each of the plurality of markers to the distal end of the probe when in the second aperture;
• process a third set of modulated reflected signals from the plurality of markers when the probe is placed in a third aperture of the plurality of apertures to determine a third set of distance values corresponding to distances from each of the plurality of markers to the distal end of the probe when in the third aperture;
• determine three-dimensional coordinates for each of the plurality of markers relative to the antenna placement template using trilateration based on the first set of distance values, the second set of distance values, and the third set of distance values and a distance between centers of the plurality of apertures.