Methods and systems for modifying electrical currents in neuronal circuits

A system, comprising:

• an ultrasound subsystem, configured to:
• apply pulses of focused ultrasound having one or more parameters to an identified location in a subject that is to receive treatment in order to modulate a level of naturally occurring hormones of the subject at the location, wherein the one or more parameters are determined in accordance with a magnetic resonance guided focused ultrasound (MRgFUS) treatment plan;
• and
• a magnetic resonance imaging (MRI) subsystem, configured to:
• acquire functional image data corresponding to the identified location concurrently with the applied pulses of focused ultrasound;
• and
• obtain a reconstructed series of functional images of the subject using the functional image data, the functional images indicative of a first region within the identified location in which neuronal activity has been modified by the applied pulses, wherein the first region is a region to be avoided in the treatment;
• wherein the system is configured to adjust one or more parameters of the MRgFUS treatment plan using the reconstructed series of functional images, including applying, using the ultrasound subsystem, focused ultrasonic pulses having one or more second parameters to a second region within the identified location, the second region distinct from the first region, wherein the second region is a region to be treated in the treatment.