Treatment of dermal glands by the application of non-thermal energy

A system comprising:

• a pulse generator configured to generate non-thermal electrical pulses having an amplitude of at least 0.1 kV and a duration of less than 1000 nanoseconds;
• an applicator comprising a treatment tip having a plurality of needle electrodes, wherein each needle electrode of the plurality of needle electrodes comprises an un-insulated portion extending from an end of an insulated portion to a distal end of each needle electrode;
• and
• a controller coupled to the pulse generator and configured to apply a treatment dose from the plurality of needle electrodes to eliminate or reduce a size of a target gland within a subject ‘s skin, wherein the treatment dose provides an energy density of 1.5 J/mm3 or less sufficient to eliminate or reduce the size of the target gland by selectively and non-thermally disrupting nuclei, organelles or outer membranes of cells of the target gland without permanently damaging structures outside the target gland.