Combined treatment with Netrin-1 interfering drug and immune checkpoint inhibitors drugs

A method of anti-cancer treatment consisting of administering to a patient in need thereof of an effective amount of an anti-netrin-1 antibody and an immunotherapeutic agent comprising an immune checkpoint inhibitor, wherein the anti-netrin-1 antibody comprises:

• (i) a variable domain VH comprising a CDR1-H of sequence SEQ ID NO:
• 5, a CDR2-H of sequence SEQ ID NO:
• 6, a CDR3-H of sequence SEQ ID NO:
• 7, and a variable domain VL comprising a CDR1-L of sequence SEQ ID NO:
• 8, a CDR2-L of sequence YAS and a CDR3-L of sequence SEQ ID NO:
• 9, or
• (ii) comprises a variable domain VH comprising a CDR1-H of sequence SEQ ID NO:
• 28, a CDR2-H of sequence SEQ ID NO:
• 29, a CDR3-H of sequence SEQ ID NO:
• 30, and a variable domain VL comprising a CDR1-L of sequence SEQ ID NO:
• 31, a CDR2-L of sequence SEQ ID NO:
• 32 and a CDR3-L of sequence SEQ ID NO:
• 9;
• wherein the immune checkpoint inhibitor is selected from the group consisting of anti-PD1, anti-PD-L1, anti-PD-L2 and anti-CTLA-4 antibodies.