Tricyclic pyridones and pyrimidones

A compound of Formula (XXIX) or pharmaceutically acceptable salt thereof:

• wherein:
• X is S(O)p, wherein p is an integer from 0 to 2;
• j is an integer from 0 to 2;
• G is selected from the group consisting of N, CH, and
• wherein G1 and G2 are independently (CH2)q, where q is 1 or 2;
• each R1 is an optional substitution independently selected from the group consisting of alkyl, cyano, cycloalkyl, halo, haloalkyl, trifluoromethyl, and alkoxy;
• Ar is aryl, N-arylamino, N-aryl-N-alkylamino, aryloxy, arylthio, heteroaryl, N-heteroarylamino, N-heteroaryl-N-alkylamino, heteroaryloxy, or heteroarylthio, any of which is optionally substituted;
• n is an integer from 0 to 2;
• R2 is selected from the group consisting of alkyl, alkylamino, dialkylamino, alkylamidoalkyl, arylamidoalkyl, alkylsulfonamidoalkyl, arylsulfonamidoalkyl, N-alkyl aminoalkyl, N,N-dialkyl aminoalkyl, alkoxy, alkoxyalkyl, cycloalkyl, alkylcycloalkyl, hydroxyalkyl, halo, haloalkyl, aralkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl any of which are optionally substituted;
• wherein when j is 1, the heterocyclylalkyl is selected from:
• m is an integer from 0 to 6;
• each R7 is independently selected from an alkyl group selected from methyl, ethyl, and propyl, any of which are optionally substituted with one or more fluorine atoms, —CH2(CH3)C═CF2, cyano, propargyl, —CH2C(O)V, wherein V is selected from methyl, OH, NHRi wherein Ri is hydrogen or alkyl;
• or any two R7 may combine to form a fused-ring, spiro or bridging bicycle, wherein any one fused-ring or bridging atom is O, S, S═O, SO2, or NRj, wherein Rj is H, methyl or trifluoromethyl;
• k is an integer from 0 to 4;
• and,
• wherein the acrylyl moiety linked to G is optionally substituted.