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US 12,119,120 B2Granted
Optimal multi-electrode transcutaneous stimulation with high focality and intensity
AssigneeThe Regents of the University of California
InventorsYing Li, Wentai Liu, Yi-Kai Lo
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Abstract
Methods, apparatus, and systems are disclosed for optimization techniques and a realistic 3D model to design optimal parameters for transcutaneous stimulation to achieve focalized stimulation of a target tissue such as the spinal cord, brain or other internal organ. The methods, apparatus, and systems include generation of a 3D model from a CT/MRI image, as well as an optimization algorithm that enables stimulation of any target location (e.g., on the dorsal root, or on the dorsal column) with any orientation at high precision.
Claims16
A system comprising:
- a stimulation array comprising multiple stimulation electrodes arranged in an array;
- a stimulator circuit configured to provide independent stimulation signals to individual electrodes in the stimulator electrode array at a plurality of frequencies, intensities, and/or waveforms;
- an external device comprising:
- a non-transitory memory storing instructions, and
- a processor configured to access the non-transitory memory and execute the instructions to at least:
- receive one or more structural images of a target treatment region of a patient when the stimulation array is placed within the target treatment region;
- generate a 3D model of the target treatment region based on the one or more structural images of the target treatment region;
- calculate, based on the 3D model of the target treatment region, a lead field matrix associated with the stimulation electrode array and the target treatment region;
- determine a safety limit for transcutaneous stimulation of the target treatment region;
- generate a set of stimulation parameters for a stimulation to be delivered by the multiple stimulation electrodes based on the lead field matrix and the safety limit, wherein the set of stimulation parameters provides both high intensity and focal accuracy within the safety limit by assigning a relative weight to directional intensity and focality of stimulation at the target treatment region;
- and
- configure the stimulator circuit to operate utilizing the generated set of stimulation parameters to deliver the stimulation with the set of stimulation parameters to the patient transcutaneously.
9 more elements
Dependencies are inferred from the claim text.