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US 12,118,694 B2Granted
Progressive exploitation of multi-energy and photon counting modalities
AssigneeElucid Bioimaging Inc.
InventorsAndrew J. Buckler, Changguo Ji, Murali Ayyapillai
Life of this patent
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Abstract
Systems and methods for improving soft tissue contrast, characterizing tissue, classifying phenotype, stratifying risk, and performing multi-scale modeling aided by multiple energy or contrast excitation and evaluation are provided. The systems and methods can include single and multi-phase acquisitions and broad and local spectrum imaging to assess atherosclerotic plaque tissues in the vessel wall and perivascular space.
Claims12
A system for implementing an analyzer module, the system comprising:
- a processor configured to:
- receive imaging data of multi-spectral Computed Tomography (CT), Magnetic Resonance (MR), or Ultrasound (US), wherein the received imaging data is obtained using different excitations;
- analyze the received imaging data to determine one or more characteristics of a vessel wall;
- determine a set of quantities that characterize vascular leak, macrophages, angiogenesis, calcification (CALC) map, lipid rich necrotic core (LRNC) map, fresh idiopathic pulmonary hemosiderosis (IPH) map, matrix (MATX) map, micro calcification, erosion, old IPH map, or thrombus or a combination thereof based on the one or more characteristics of the vessel wall, using digital subtraction, digital addition, a multivariate statistical process, excitation selection process or a combination thereof;
- and
- output the characterization of vascular leak, macrophages, angiogenesis, CALC map, LRNC map, fresh IPH map, MATX map, micro calcification, erosion, old IPH map, or thrombus to a display.
3 more elements
A method for implementing analyzing soft tissue, the method comprising
- receiving, by a processor, imaging data of multi-spectral Computed Tomography (CT), Magnetic Resonance (MR), or Ultrasound (US), wherein the received imaging data is obtained using different excitations;
- analyzing, by the processor, the received imaging data to determine one or more characteristics of a vessel wall;
- determining, by the processor, a set of quantities that characterize vascular leak, macrophages, angiogenesis, calcification (CALC) map, lipid rich necrotic core (LRNC) map, fresh idiopathic pulmonary hemosiderosis (IPH) map, matrix (MATX) map, micro calcification, erosion, old IPH map, or thrombus or a combination thereof based on the one or more characteristics of the vessel wall, using digital subtraction, digital addition, a multivariate statistical process, excitation selection process or a combination thereof;
- and
- outputting, by the processor, the vascular leak, macrophages, angiogenesis, CALC map, LRNC map, fresh IPH map, MATX map, micro calcification, erosion, old IPH map, or thrombus to a display.
2 more elements
Dependencies are inferred from the claim text.