System and method for non-invasive quantification of blood biomarkers

A program storage device readable by machine, tangibly embodying a program of instructions executable by the machine to perform a method for determining levels of blood biomarkers, comprising:

• (a) providing spectrogram data indicative of near infra-red absorption of a patient's tissue;
• (b) using one or more pre-trained prediction models comprising a selected number of prediction routes for processing the spectrogram data, and determining prediction data on a selected group of biomarkers accordingly;
• (c) determining one or more biomarkers associated with a number of groups and for the one or more biomarkers associated with a number of groups, determining an average concentration data of in accordance with the prediction data of a number of prediction routes associated with said number of groups;
• and
• generating output data indicative of estimated levels of a selected set of biomarkers for said patient.

A computer program product comprising a computer useable medium having computer readable program code embodied therein for determining levels of blood biomarkers, the computer program product comprising:

• computer readable program code for causing the computer to provide spectrogram data indicative of near infra-red absorption of a patient's tissue;
• computer readable program code for causing the computer to use one or more pre-trained prediction models comprising a selected number of prediction routes to process the spectrogram data and to determine prediction data on a selected group of biomarkers;
• computer readable program code for causing the computer to determine one or more biomarkers associated with a number of groups and to determine an average concentration data of said one or more biomarkers in accordance with the prediction data being output of a number of prediction routes associated with said number of groups;
• and
• computer readable program code for causing the computer to generate output data indicative of estimated levels of a selected set of biomarkers for said patient.

A system for non-invasive determining of levels of blood biomarkers comprising:

• a processor and memory circuitry (PMC), wherein the PMC comprises a pre-stored prediction model, and is configured to:
• (a) obtain spectrogram data indicative of near infra-red absorption of a patient's tissue;
• (b) use one or more pre-trained prediction models comprising a selected number of prediction routes comprising prediction routes pre-trained for predicting data on selected groups of biomarkers, being different between said prediction routes, and determining prediction data on a selected group of biomarkers;
• (c) determine one or more biomarkers associated with a number of groups and determine for each of the one or more biomarkers an average concentration data of said one or more biomarkers in accordance with the prediction data being output of a number of prediction routes associated with said number of groups;
• and
• (d) generate output data indicative of estimated levels of a selected set of biomarkers for said patient.