Systems and methods for anatomic structure segmentation in image analysis

A system for performing machine-learning based anatomic structure segmentation in image analysis, comprising:

• at least one memory storing instructions and a Convolutional Neural Network (CNN);
• and
• at least one processor operatively connected to the at least one memory and configured to execute the instructions to perform operations, including:
• receiving image data of an anatomic structure of a patient;
• obtaining an annotation of the anatomic structure;
• determining, based on the annotation, one or more keypoints;
• determining a respective distance between each keypoint and a boundary of the anatomic structure;
• determining respective intensities along a respective ray associated with each keypoint;
• training the CNN, based on the respective distance and the respective intensities of each keypoint, to be patient-specific and to predict sub-pixel or sub-voxel locations of the boundary of the anatomic structure;
• and
• generating, using the trained patient-specific CNN a sub-pixel or sub-voxel boundary of the anatomic structure.

A non-transitory computer-readable medium comprising instructions for machine-learning based anatomic structure segmentation in image analysis, the instructions executable by one or more processors to perform operations, including:

• receiving image data of an anatomic structure of a patient;
• obtaining an annotation of the anatomic structure;
• determining, based on the annotation, one or more keypoints;
• determining a respective distance between each keypoint and a boundary of the anatomic structure;
• determining respective intensities along a respective ray associated with each keypoint;
• training a patient-specific Convolutional Neural Network (CNN), based on the respective distance and the respective intensities of each keypoint, to predict sub-pixel or sub-voxel locations of the boundary of the anatomic structure;
• and
• generating, using the trained patient-specific CNN a sub-pixel or sub-voxel boundary of the anatomic structure.