US 12,110,562 B2Granted

Compositions and methods for predicting and promoting weight loss

AssigneeUniversity of Copenhagen

InventorsMads Fiil Hjorth, Arne Vernon Astrup, Yishai Zohar

Life of this patent

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Abstract

The invention provides methods for identifying biomarkers in a patient's microbiota to predict a patient's response to a predetermined diet to promote weight loss and methods of promoting weight loss in the patient by optimizing the patient's diet in accordance with the biomarkers identified in the patient's gut microbiota. The methods of the invention can also be used to manage or maintain weight, i.e., prevent or inhibit weight gain, in a patient who is of normal weight or is overweight or obese.

Claims3

Dependent claims

A method of promoting weight loss in a patient wherein the patient has been identified as having at least one of:

(a) a gut microbiota with a relative abundance of log 10 (Prevotella spp.) of greater than −3, (b) a gut microbiota with a relative abundance of log 10 (Prevotella spp./Bacteroides spp.) of greater than −2, (c) a gut microbiota with a relative abundance of Log 10 (Prevotella spp./Bacteroidetes all) of greater than −2, and (d) a gut microbiota with a relative abundance of Log 10(Bacteroidetes all/Bacteroides spp.) of greater than 0, comprising the steps of;
(a) determining the patient's fasting plasma glucose (FPG) and fasting insulin level (FI);
and
(b) administering to the patient a predetermined diet, wherein
(i) the patient's FPG is less than about 90 mg/dL, the patient's FI is below about 9.5 uU/mL and the predetermined diet is Diet 1;
(ii) the patient's FPG is less than about 90 mg/dL, the patient's FI is above about 13 uU/mL, and the predetermined diet is Diet 2;
(iii) the patient's FPG is between about 90 and 100 mg/dL, the patient's FI is above about 13 uU/mL and the predetermined diet is Diet 4;
(iv) the patient's FPG is between about 100 and 115 mg/dL, the patient's FI is below about 9.5 uU/mL and the predetermined diet is Diet 5;
(v) the patient's FPG is between about 100 and 115 mg/dL, the patient's FI is above about 13 uU/mL and the predetermined diet is Diet 6;
(vi) vi the patient's FPG is between about 115 and 125 mg/dL, the patient's FI is below about 9.5 uU/mL and the predetermined diet is Diet 7;
(vii) vii the patient's FPG is between about 115 and 125 mg/dL, the patient's FI is above about 13 uU/mL and the predetermined diet is Diet 8;
(viii) the patient's FPG is greater than about 125 mg/dL, the patient's FI is below about 9.5 uU/mL and the predetermined diet is Diet 9;
(ix) the patient's FPG is greater than about 125 mg/dL, the patient's FI is above about 13 uU/mL and the predetermined diet is Diet 10;
(x) the patient's FPG is less than about 90 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 1 or Diet 2;
(xi) the patient's FPG is between about 90 and 100 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 4;
(xii) the patient's FPG is between about 100 and 115 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 5 or Diet 6;
(xiii) the patient's FPG is between about 115 and 125 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 7 or Diet 8;
or
(xiv) the patient's FPG is greater than about 125 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 9 or Diet 10;
wherein diets 1, 2 and 4-10 are defined in the table below:
Diet 1
Carbohydrate:
52-56%
Protein:
19-23%
Fat:
23-27%
Fiber:
>30 g/10 MJ
Added sugar:
<15E%
Diet 2
Carbohydrate:
28-32%
Protein:
23-27%
Fat:
43-47%
Fiber:
>20 g/10 MJ
Added sugar:
<5E%
Diet 4
Carbohydrate:
38-42%
Protein:
23-27%
Fat:
33-37%
Fiber:
>25 g/10 MJ
Added sugar:
<10E%
Diet 5
Carbohydrate:
42-46%
Protein:
19-23%
Fat:
33-37%
Fiber:
>30 g/10 MJ
Added sugar:
<15E%
Diet 6
Carbohydrate:
35-39%
Protein:
23-27%
Fat:
36-40%
Fiber:
>25 g/10 MJ
Added sugar:
<10E%
Diet 7
Carbohydrate:
37-41%
Protein:
19-23%
Fat:
38-42%
Fiber:
>30 g/10 MJ
Added sugar:
<10E%
Diet 8
Carbohydrate:
31-35%
Protein:
23-27%
Fat:
40-44%
Fiber:
>20 g/10 MJ
Added sugar:
<5E%
Diet 9
Carbohydrate:
32-36%
Protein:
19-23%
Fat:
43-47%
Fiber:
>25 g/10 MJ
Added sugar:
<5E%
Diet 10
Carbohydrate:
28-32%
Protein:
23-27%
Fat:
43-47%
Fiber:
>20 g/10 MJ
Added sugar:
<5E%

116 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/992,496Filed 30 May 2018 · us provisional application
Priority: 1 Jun 2017
Published: US 2019/0062811 A128 Feb 2019
Granted: 8 Oct 2024
Term ends: Not estimatedThe source records don’t support an estimate.

Classification16 codes

C12Q 1/689
For detection or identification of organisms: for bacteria
A23L 33/135
Using additives: bacteria or derivatives thereof, e.g. probiotics
A23L 33/21
Reducing nutritive value; Dietetic products with reduced nutritive value: addition of substantially indigestible substances, e.g. dietary fibres
A23L 33/30
Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof: dietetic or nutritional methods, e.g. for losing weight

Family

Application62/513,743Us provisional application · filed 1 Jun 2017
Application62/550,925Us provisional application · filed 28 Aug 2017
Application62/594,172Us provisional application · filed 4 Dec 2017
Application62/646,884Us provisional application · filed 22 Mar 2018
US 2019/0062811 A1Pre-grant publication · published 28 Feb 2019
US 12,110,562 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

A method of promoting weight loss in a patient wherein the patient has been identified as having at least one of:

(a) a gut microbiota with a relative abundance of log 10 (Prevotella spp.) of greater than −3, (b) a gut microbiota with a relative abundance of log 10 (Prevotella spp./Bacteroides spp.) of greater than −2, (c) a gut microbiota with a relative abundance of Log 10 (Prevotella spp./Bacteroidetes all) of greater than −2, and (d) a gut microbiota with a relative abundance of Log 10(Bacteroidetes all/Bacteroides spp.) of greater than 0, comprising the steps of;
(a) determining the patient's fasting plasma glucose (FPG) and fasting insulin level (FI);
and
(b) administering to the patient a predetermined diet, wherein
(i) the patient's FPG is less than about 90 mg/dL, the patient's FI is below about 9.5 uU/mL and the predetermined diet is Diet 1;
(ii) the patient's FPG is less than about 90 mg/dL, the patient's FI is above about 13 uU/mL, and the predetermined diet is Diet 2;
(iii) the patient's FPG is between about 90 and 100 mg/dL, the patient's FI is above about 13 uU/mL and the predetermined diet is Diet 4;
(iv) the patient's FPG is between about 100 and 115 mg/dL, the patient's FI is below about 9.5 uU/mL and the predetermined diet is Diet 5;
(v) the patient's FPG is between about 100 and 115 mg/dL, the patient's FI is above about 13 uU/mL and the predetermined diet is Diet 6;
(vi) vi the patient's FPG is between about 115 and 125 mg/dL, the patient's FI is below about 9.5 uU/mL and the predetermined diet is Diet 7;
(vii) vii the patient's FPG is between about 115 and 125 mg/dL, the patient's FI is above about 13 uU/mL and the predetermined diet is Diet 8;
(viii) the patient's FPG is greater than about 125 mg/dL, the patient's FI is below about 9.5 uU/mL and the predetermined diet is Diet 9;
(ix) the patient's FPG is greater than about 125 mg/dL, the patient's FI is above about 13 uU/mL and the predetermined diet is Diet 10;
(x) the patient's FPG is less than about 90 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 1 or Diet 2;
(xi) the patient's FPG is between about 90 and 100 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 4;
(xii) the patient's FPG is between about 100 and 115 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 5 or Diet 6;
(xiii) the patient's FPG is between about 115 and 125 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 7 or Diet 8;
or
(xiv) the patient's FPG is greater than about 125 mg/dL, the patient's FI is between about 9.5 to about 13 uU/mL, and the predetermined diet is Diet 9 or Diet 10;
wherein diets 1, 2 and 4-10 are defined in the table below:
Diet 1
Carbohydrate:
52-56%
Protein:
19-23%
Fat:
23-27%
Fiber:
>30 g/10 MJ
Added sugar:
<15E%
Diet 2
Carbohydrate:
28-32%
Protein:
23-27%
Fat:
43-47%
Fiber:
>20 g/10 MJ
Added sugar:
<5E%
Diet 4
Carbohydrate:
38-42%
Protein:
23-27%
Fat:
33-37%
Fiber:
>25 g/10 MJ
Added sugar:
<10E%
Diet 5
Carbohydrate:
42-46%
Protein:
19-23%
Fat:
33-37%
Fiber:
>30 g/10 MJ
Added sugar:
<15E%
Diet 6
Carbohydrate:
35-39%
Protein:
23-27%
Fat:
36-40%
Fiber:
>25 g/10 MJ
Added sugar:
<10E%
Diet 7
Carbohydrate:
37-41%
Protein:
19-23%
Fat:
38-42%
Fiber:
>30 g/10 MJ
Added sugar:
<10E%
Diet 8
Carbohydrate:
31-35%
Protein:
23-27%
Fat:
40-44%
Fiber:
>20 g/10 MJ
Added sugar:
<5E%
Diet 9
Carbohydrate:
32-36%
Protein:
19-23%
Fat:
43-47%
Fiber:
>25 g/10 MJ
Added sugar:
<5E%
Diet 10
Carbohydrate:
28-32%
Protein:
23-27%
Fat:
43-47%
Fiber:
>20 g/10 MJ
Added sugar:
<5E%

116 more elements

Facts

Application

15/992,496Filed 30 May 2018 · us provisional application

Priority

1 Jun 2017

Published

US 2019/0062811 A128 Feb 2019

Granted

8 Oct 2024

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

C12Q 1/689
For detection or identification of organisms: for bacteria
A23L 33/135
Using additives: bacteria or derivatives thereof, e.g. probiotics
A23L 33/21
Reducing nutritive value; Dietetic products with reduced nutritive value: addition of substantially indigestible substances, e.g. dietary fibres
A23L 33/30
Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof: dietetic or nutritional methods, e.g. for losing weight

Family

Application62/513,743Us provisional application · filed 1 Jun 2017

Application62/550,925Us provisional application · filed 28 Aug 2017

Application62/594,172Us provisional application · filed 4 Dec 2017

Application62/646,884Us provisional application · filed 22 Mar 2018

US 2019/0062811 A1Pre-grant publication · published 28 Feb 2019

US 12,110,562 B2This patent

From the US filing history. Foreign family members aren’t listed.