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US 12,110,344 B2Granted
Antibodies that bind to cis and uses thereof
AssigneeDianthus Therapeutics Opco, Inc.
InventorsVahe Bedian, Charles A. Omer
Life of this patent
Estimating the term…
Abstract
Embodiments that are provided for herein relate to antibodies and compositions that bind to C1s. Also provided are methods of producing the antibodies of the present disclosure, as well as uses of the provided antibodies and compositions for the treatment of C1s mediated diseases and disorders.
Claims25
An antibody, or an antigen binding fragment thereof, wherein the antibody, or the antigen binding fragment thereof, comprises:
- a heavy chain variable region comprising heavy chain HCDR1, HCDR2, and HCDR3 sequences, wherein the HCDR1 has the amino acid sequence of SEQ ID NO:
- 61, the HCDR2 has the amino acid sequence of SEQ ID NO:
- 62, and the HCDR3 has the amino acid sequence of SEQ ID NO:
- 78;
- and
- a light chain variable region comprising light chain LCDR1, LCDR3, and LCDR3 sequences, wherein the LCDR1 has the amino acid sequence of SEQ ID NO:
- 64, the LCDR2 has the amino acid sequence of SEQ ID NO:
- 65, and the LCDR3 has the amino acid sequence of SEQ ID NO:
- 79.
6 more elements
Dependencies are inferred from the claim text.